Description 
The exogenous promoter and mouse Abcb1b coding sequence were inserted into the mouse genome randomly. Mouse Abcb1b is highly expressed on the surface of B-Tg(mAbcb1b) MC38 cells.
Application
B-Tg(mAbcb1b) MC38 cells have the capability to establish tumors in vivo and can be used for efficacy studies.
Targeting strategy
Gene targeting strategy for B-Tg(mAbcb1b) MC38 cells. The exogenous promoter and mouse Abcb1b coding sequence were inserted into the mouse genome randomly. 
Tumor growth curve & Body weight changes

Subcutaneous homograft tumor growth of B-Tg(mAbcb1b) MC38 cells. B-Tg(mAbcb1b) MC38 cells (5x10⁵) and wild-type MC38 cells (5x10⁵) were subcutaneously implanted into C57BL/6 mice (female, 8-week-old, n=6). Tumor volume and body weight were measured twice a week. (A) Average tumor volume ± SEM. (B)  Body weight (Mean± SEM). Volume was expressed in mm³ using the formula: V=0.5 X long diameter X short diameter². As shown in panel A, B-Tg(mAbcb1b) MC38 cells were able to establish tumors in vivo and can be used for efficacy studies.