Establishment of special diet-induced atherosclerosis model in ApoE-/- mice
(A-B) Atherosclerotic plaques of mice at 12 and 20 weeks.(C-D) Oil Red results of aortic sinus at 12 and 20 weeks. (E) Gross staining of aortic arch at 12 weeks.
Tissue staining and blood biochemical results in the mouse model of atherosclerosis at 12 weeks (A) H&E results of aortic sinus Increased. (B-C) Immunohistochemistry shows expression of α-SMA and F4/80. (D) ALT, AST, TC, TG, HDL-C and LDL-C levels in serum. Values are expressed as mean ± SEM. **p<0.01, ****p<0.0001.